Lubrication in prefilled syringes can cause adverse effects on various pharmaceutical drugs, alter immunologic response and ultimately affect patient safety.

The lubrigone stopper enables prefilled syringes without lubricated or coated components.

Despite the elimination of lubrication lubrigone offers a high degree of user-friendliness during injection administration.

• Reduced risk of protein aggregation
• Compliant with glass or polymer (COC/COP)
• Low break-loose and gliding forces


lubrigone is a completely lubrication free, and coating free solution that provides container closure integrity and a low break loose force even after a long shelf life.

It is based on a special medical grade thermoplastic elastomer that combined with the special design provides excellent performance required for prefillable syringes.

It offers a completely lubrication free solution, hence the best way to protect pharmaceutical and biologic liquid injectables against potential adverse effects, such as the risk of protein aggregation.


Would you like to know more…
Besides our data sheet, we have extensive test reports on extractables, container closure integrity, break loose and gliding forces.
Please send us a mail with information about your company, purpose and interest.

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Silicone oil free, coating free performance

Existing prefillable syringe systems on the market predominantly use traditional stoppers, which have a strong adhesiveness towards especially glass but also polymer container materials, necessitating the use of lubrication means to ensure satisfactory operating forces without any potential discomfort to the patient.

Some drug formulations are sensitive to silicone oil or coatings and may interact with the silicone oil droplet surface which thereby cause an irreversible change in conformation leading to insoluble protein aggregation and loss of monomers. This causes an adverse effect on the drug, which may alter the immunogenic response and reduce drug efficiency.

lubrigone’s novel combination of the sealing profile design and special material characteristics comprise a solution with low static and dynamic forces without the traditional need for silicone oil or coating of the stopper and container, resulting in a clean injection system.

Furthermore, the silicone oil free and coating free solution maintain uniform behavior after long-term storage.

Holding-syringe lubrigone3

Injecto A/S
Pharmaceutical Packaging
Strandvejen 60, 5.
2900 Hellerup

Phone: +45 2785 1000
Email: info@injecto.eu
CVR/Org. No.: DK-38 72 98 88


INJECTO can deliver prefillable syringes and syringe components for ready-to-use liquid injectables

Clean injection systems...
Our components are high-precision injection moulded and can be provided for syringe solutions that are lubrication free, coating free, silicone oil free and baked-on silicone free

Feel free to contact INJECTO for more information

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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 875949